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Tacrolimus is soluble in methanol, ethanol, acetone, ethyl acetate, and ether, and it is practically insoluble in water.

Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.